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Title   한국인 대장암의 예후인자 및 생존율 ( Survival Rates in Korean Patients with Colorectal Cancer )
Publicationinfo   1993 Jan; 025(03): 350-359.
Key_word   Colon cancer, rectal cancer, prognosis, staging, multivariate analysis
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Abstract   To address the status of colorectal cancer in Korea, this study evaluated the survival by clinicopathologic variables which were obtained from the records of 369 patients treated in the seven leading hospitals of Seoul, Korea, during the period from Jan 1, 1985 to Dec 31, 1985. Overall five year survival rate was 60.7%. Median age was 53.0 years old and median duration of symptom was 5.0 months. Fourteen percent of all colorectal cancers were under the age of 40. The median diameter of tumor was 5.0cm(95% CI; 5.5-6.0cm). Half of the patients had Borrmann type II. Early colonic cancer consisted 2.5% of all cancers. Eighty percent of the tu- mors invaded through the colonic walL Eighty two percent among the 361 patients had curative or palliative resections. Curative resection was possible in 264 patients and its 5 year survial rate was 61.6%. Postoperative adjuvant therapy did not help for the prolongation of survival in Dukes stage C of these cases. In univariate analyses, the factors associated with significant outcome were rectal bleeding, obstructive symptoms, preoperative elevation of CEA, type of histopathology, depth of tumor invasion, number of tumor positive lymph nodes, Dukes' stage and extent of operation. But multivariate analysis with Cox proportional hazard model involving l98 patients identified five factors that were associated with significantly favorable effect on survival: well and moderate differentiated adenocarcinoma, Dukes stage B2 and Cl, none of the positive node, depth of invasion which confined to proper muscle, curative resection. Depth of invssion was more important for the survival than the number of tumor positive lympb nodes. A staging classification appears feasible to determine outcome in patients with colorectal cancer.
저 자   이봉화(Bong Hwa Lee),우제홍(Ze Hong Woo),김태수(Tae Soo Kim),박용범(Eung Bum Park),전규영(Kyu Young Jun),김광연(Kwang Yun Kim),이기형(Kee Hyung Lee),박재갑(Jae Gahb Park),이경식(Kyung Sik Lee)